4 血浆外泌体miRNA在小鼠模型中和内侧颞叶癫痫患者中的表达和潜在作用 Expression and Potential Function of Plasma Exosomal microRNAs (miR-483-5p, miR-671-5p, and miR-150-3p) in a Mouse Mode and in Mesial Temporal Lobe Epilepsy Patients
期刊：Cell Death & Disease
影响因子：5.378
文章简介
It was found that exosomal miRNAs were differentially expressed in three phases of the mouse mode, and exosomal miRNAs were down-regulated in mTLE patients compared with healthy controls. A bioinformatics analysis showed that target genes of exosomal miRNAs were significantly involved in the apoptotic process, cell adhesion, nervous system development, neurotrophin signaling pathway, PI3K-Akt signaling pathway, and metabolic pathways. The areas under the curve of miR-483-5p and miR-150-3p were 0.8714 (sensitivity = 75.00%, specificity = 91.65%) and 0.8213 (sensitivity = 67.50%, specificity = 90.00%), respectively.
5 循环的外泌体miRNA-96通过靶向LMO7促进细胞增殖、迁移和耐药性 Circulating exosomal microRNA-96 promotes cell proliferation, migration and drug resistance by targeting LMO7
期刊：journal of cellular and molecular medicine
影响因子：4.938
文章简介
We have identified exosomal miR-96 as a serum biomarker of malignant lung cancer. MiR-96 promotes lung cancer progression by targeting LMO7. The miR-96-LMO7 axis may be a therapeutic target for lung cancer patients, and new diagnostic or therapeutic strategies could be developed by targeting the miR-96-LMO7 axis.
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6 肌细胞来源的Hsp90在心脏肥大时通过激活成纤维细胞STAT-3调控胶原蛋白上调 Myocyte derived Hsp90 modulates collagen upregulation via biphasic activation of STAT-3 in fibroblasts during cardiac hypertrophy
期刊：molecular and cellular biology
影响因子：4.427
文章简介
Such myocyte derived exosomes along with myocyte secreted IL-6 are responsible in unison for the biphasic activation of STAT-3 signalling in cardiac fibroblasts that culminates in excess collagen synthesis leading to severely compromised cardiac function during cardiac hypertrophy.*此文章PDF大于论坛限制的附件大小，无法上传。PMID: 28031326 DOI: 10.1128/MCB.00611-16
