外泌体之家 | 细胞外膜泡领域核心平台—exosomes & microvesicles—小膜泡大作用

标题: 外泌体miRNA分选机制 [打印本页]

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作者: bunny    时间: 2018-7-20 15:58
标题: 外泌体miRNA分选机制

Cell report September 25, 2014

NontemplatedNucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes

样品：human   Lymphoblastoid B-cell EBV+; Burkitt LymphomaEBV+; Diffuse Large B-cell Lymphoma

highlights：

1、3' endadenylation increases the probability for retention in cells, and this probability increases proportionally with the number of added A's.

2、3'-end uridylatedmiRNA isoforms are overrepresented in exosomes

3、NTA modifications act as a small RNA sorting signal beyond the class of miRNAs, also found in Y RNAs.

4、Enrichment of 3' uridylated miRNAs in exosomes may thus be explained by preferentialrelease or could be due to a high turnover incells compared to exosomes.

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作者: yfsx    时间: 2018-7-27 11:09
谢谢楼主的分享。

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