外泌体之家 | 细胞外膜泡领域核心平台—exosomes & microvesicles—小膜泡大作用

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【免费】外泌体学院之大咖分享第17期——大蒜外泌体抗衰...

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发表于 2023-7-28 22:14:00 | 显示全部楼层 |阅读模式
【免费报名】外泌体学院之大咖分享第十七期——大蒜外泌体抗衰老机制
2023年8月3日(周四)  上午9 : 30
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内容简介
Today his talk will cover two areas:
1.    Numerous and diversified proteins are releasedfrom exosome producingcells and these proteinsserve an important role in human physiology and pathophysiology. However, whetherthe molecules containedin exosomes have the same biological effect on the recipient cells as in the exosomeproducing cells is largely unknown. Moreover, less understood is if a leader moleculeis present in exosomes and what its role. Filling in this key gap in our current knowledge would further clarify the molecular basis of the unique biological effects mediated by exosomes on the recipient cells and add to the current conceptual framework of exosomal biology
2.   Chronic non-resolving inflammation with widespread microglial activation is a defining feature of central nervous system (CNS) diseases. Microglial cells, the most abundant type of immune cell in the brain, play important roles in brain development, maintenance, and disease. These cells also respond vigorously to both chronic disease and acute insults affecting the CNS.
A healthy diet inhibits brain inflammation, understanding the molecular and physiological mechanisms that underlie the effects of a healthy diet on brain function via the diet-gut-brain axis has been a priority of researchers for many years. Understanding the mechanisms that underlie the beneficial effects of a healthy diet on prevention of chronic inflammation of the brain may enable the creation of dietary or pharmaceutical interventions to improve brain function. Here, a garlic exosome-like nanoparticle (GaELNs) was used as proof-of-concept to studythe effect of GaELNs on microglial cells and the resulting effects on chronic inflammation of the brain.
主讲人简介

Huang-Ge Zhang Ph.D
Huang-Ge Zhang, Ph.D., A Research Career Scientist, a tenured Professor of Department of Microbiology & Immunology at the University of Louisville, and endowed professor of microbiology and immunology and senior scientist at the Brown Cancer Center at the University of Louisville and ranked as the one of Best Immunology Scientists in the world
He publishedthe first exosomesbook as Editor-in-Chief, entitled “Emerging Conceptsof Tumor Exosome-Mediated Cell-Cell Communication”, Springer Science, 2013.
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